A nontoxic Pseudomonas exotoxin A induces active immunity and passive protective antibody against Pseudomonas exotoxin A intoxication.

@article{Chen1999ANP,
  title={A nontoxic Pseudomonas exotoxin A induces active immunity and passive protective antibody against Pseudomonas exotoxin A intoxication.},
  author={T Y Chen and Charles P. Lin and Chien Chang Loa and T L Chen and H F Shang and J Hwang and Celine Fan Fong Hui},
  journal={Journal of biomedical science},
  year={1999},
  volume={6 5},
  pages={357-63}
}
Pseudomonas exotoxin A (PE) is one of the most potent cytotoxic agents produced by Pseudomonas aeruginosa. In this study, we examined the possibility of using PE with a deletion of 38 carboxyl-terminal amino acid residues, designated PE(Delta576-613), for active immunization against PE-mediated disease. We first examined the toxic effects of PE and PE(Delta576-613) on 5- and 9-week-old ICR mice. The results show that the subcutaneous administration of PE(Delta576-613) at a dose of 250 microg… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…