A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection.

@article{Jonji1988ANV,
  title={A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection.},
  author={Stipan Jonji{\'c} and M del Val and G{\"u}nther M. Keil and Matthias Johannes Reddehase and Ulrich Koszinowski},
  journal={Journal of virology},
  year={1988},
  volume={62 5},
  pages={1653-8}
}
The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89 is also the dominant antigen recognized by MCMV-specific cytolytic T lymphocytes. The recombinant vaccinia virus MCMV-ieI-VAC, which expresses pp89, was used to study the capacity of this protein to induce protective immunity in BALB/c mice… CONTINUE READING