A nonribosomal system of peptide biosynthesis.

@article{Kleinkauf1996ANS,
  title={A nonribosomal system of peptide biosynthesis.},
  author={H. Kleinkauf and H. von D{\"o}hren},
  journal={European journal of biochemistry},
  year={1996},
  volume={236 2},
  pages={
          335-51
        }
}
This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures. The respective enzyme systems are constructed of biosynthetic modules integrated into multienzyme structures. Genetic and DNA-sequence analysis of biosynthetic gene clusters have revealed… Expand
Engineering of Peptide Synthetases
Biosynthetic systems for nonribosomal peptide antibiotic assembly.
Protein templates for the biosynthesis of peptide antibiotics.
The Modular Organization of Multifunctional Peptide Synthetases
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