A nonribosomal system of peptide biosynthesis.

  title={A nonribosomal system of peptide biosynthesis.},
  author={Horst Kleinkauf and Hans von D{\"o}hren},
  journal={European journal of biochemistry},
  volume={236 2},
This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures. The respective enzyme systems are constructed of biosynthetic modules integrated into multienzyme structures. Genetic and DNA-sequence analysis of biosynthetic gene clusters have revealed… CONTINUE READING