A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus.

@article{RamirezOrtiz2011ANR,
  title={A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus.},
  author={Zaida G. Ramirez-Ortiz and Chrono K. Lee and Jennifer P. Wang and Louis Boon and Charles A. Specht and Stuart M Levitz},
  journal={Cell host & microbe},
  year={2011},
  volume={9 5},
  pages={415-24}
}
While plasmacytoid dendritic cells (pDCs), a natural type I interferon (IFN)-producing cell type, are regarded as critical for innate immunity to viruses, their role in defense against fungal infections remains unknown. We examined the interactions of pDCs with hyphae of the invasive human fungal pathogen Aspergillus fumigatus. Human pDCs spread over hyphae and inhibited their growth. Antifungal activity was retained in pDC lysates, did not require direct fungal contact, and was partially… CONTINUE READING
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a 2011 Elsevier In the dectin1 betaglucan receptor in pulmonary defense against Aspergillus fumigatus

  • K. L. Wozniak, J. M. Vyas, S. M. Levitz
  • J . Immunol .
  • 2011

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