A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.

@article{Pals1983ANP,
  title={A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.},
  author={D. T. Pals and John Orley},
  journal={Journal of pharmacological methods},
  year={1983},
  volume={9 3},
  pages={183-92}
}
The potential of several classes of antihypertensive drugs to cause orthostatic hypotension in man was evaluated in a conscious cynomolgus monkey model. Supine and erect blood pressure and heart rate were continuously monitored before and after administration of chlorisondamine (a ganglionic blocking agent); phentolamine and prazosin (alpha-adrenergic blocking agents); propranolol (a beta-adrenergic blocking agent); and minoxidil (a vasodilator). Substantial validation of the model was… CONTINUE READING
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