A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

@article{Hjelmeland1980ANZ,
  title={A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.},
  author={Leonard M. Hjelmeland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 11},
  pages={6368-70}
}
The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.