A noncytotoxic DsRed variant for whole-cell labeling

  title={A noncytotoxic DsRed variant for whole-cell labeling},
  author={Rita L. Strack and Daniel E. Strongin and Dibyendu Bhattacharyya and Wen Tao and Allison Berman and Hal E. Broxmeyer and Robert J. Keenan and Benjamin S. Glick},
  journal={Nature Methods},
A common application of fluorescent proteins is to label whole cells, but many RFPs are cytotoxic when used with standard high-level expression systems. We engineered a rapidly maturing tetrameric fluorescent protein called DsRed-Express2 that has minimal cytotoxicity. DsRed-Express2 exhibits strong and stable expression in bacterial and mammalian cells, and it outperforms other available RFPs with regard to photostability and phototoxicity. 
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