A noncovalent complex vaccine prepared with detoxified Escherichia coli J5 (Rc chemotype) lipopolysaccharide and Neisseria meningitidis Group B outer membrane protein produces protective antibodies against gram-negative bacteremia.

@article{Bhattacharjee1996ANC,
  title={A noncovalent complex vaccine prepared with detoxified Escherichia coli J5 (Rc chemotype) lipopolysaccharide and Neisseria meningitidis Group B outer membrane protein produces protective antibodies against gram-negative bacteremia.},
  author={Apurba K. Bhattacharjee and Steven M. Opal and Rosa Taylor and Robert B Naso and Mark Semenuk and Wendell D. Zollinger and Elizabeth E. Moran and Lynn Young and C A Hammack and Jerald C. Sadoff and Alan S. Cross},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 5},
  pages={1157-63}
}
Earlier studies showed that purified IgG from sera of rabbits immunized with a boiled Escherichia coli J5 (Rc chemotype) whole cell vaccine protected neutropenic rats against gram-negative bacterial sepsis. In the present study, de-O-acylated J5 lipopolysaccharide (J5 DLPS) as a noncovalent complex with Neisseria meningitidis group B outer membrane protein (GBOMP) elicited anti-J5 LPS antibodies in rabbits. IgG prepared from immune rabbit sera protected neutropenic rats against lethal challenge… CONTINUE READING

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