A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.

@article{Gradolatto2009ANB,
  title={A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.},
  author={Angeline Gradolatto and Sherri K Smart and Stephanie D. Byrum and Lauren P. Blair and Richard S. Rogers and Elizabeth A Kolar and Heather Lavender and Signe K Larson and John D. Aitchison and Sean D. Taverna and Alan J. Tackett},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 17},
  pages={4604-11}
}
Saccharomyces cerevisiae Yta7 is a barrier active protein that modulates transcriptional states at the silent mating locus, HMR. Additionally, Yta7 regulates histone gene transcription and has overlapping functions with known histone chaperones. This study focused on deciphering the functional role of the noncanonical Yta7 bromodomain. By use of genetic and epistasis analyses, the Yta7 bromodomain was shown to be necessary for barrier activity at HMR and to have overlapping functions with… CONTINUE READING

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