A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia.

@article{Shanmugam2012ANF,
  title={A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia.},
  author={Rajasubramaniam Shanmugam and Padmaja Gade and Annique Wilson-Weekes and Hamid Sayar and Attaya Suvannasankha and Chirayu Pankaj Goswami and Lang Li and Sushil Gupta and Angelo De Almeida Cardoso and Tareq Al Baghdadi and Katie J. Sargent and Larry Dean Cripe and Dhananjaya V R Kalvakolanu and H. Scott Boswell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 2},
  pages={
          360-369
        }
}
PURPOSE Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in several tumors. A mechanistic basis for epigenetic/transcriptional repression of DAPK1 was investigated in certain forms of acute myeloid leukemia (AML) with poor prognosis, which lacked ER stress-induced apoptosis. EXPERIMENTAL DESIGN Heterogeneous primary AMLs were screened to… CONTINUE READING
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