A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development.

Abstract

PURPOSE Frizzled-5 (Fzd5) is expressed in the developing retina of multiple species and appears to play species-specific roles during eye development. The present study analyzed the effects of tissue-specific deletion of Fzd5 on mammalian eye development. METHODS To generate Fzd5 conditional knockout (CKO) mice, Fzd5(+/-) mice carrying the Six3-Cre… (More)
DOI: 10.1167/iovs.08-2226

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