A nonapoptotic role for CASP2/caspase 2

  title={A nonapoptotic role for CASP2/caspase 2},
  author={Meenakshi Tiwari and Lokendra Kumar Sharma and Difernando Vanegas and Danielle A. Callaway and Yidong Bai and James D Lechleiter and Brian A. Herman},
CASP2/caspase 2 plays a role in aging, neurodegeneration, and cancer. The contributions of CASP2 have been attributed to its regulatory role in apoptotic and nonapoptotic processes including the cell cycle, DNA repair, lipid biosynthesis, and regulation of oxidant levels in the cells. Previously, our lab demonstrated CASP2-mediated modulation of autophagy during oxidative stress. Here we report the novel finding that CASP2 is an endogenous repressor of autophagy. Knockout or knockdown of CASP2… CONTINUE READING


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