111 Citations
The orbitofrontal cortex: reward, emotion and depression
- Psychology, BiologyBrain communications
- 2020
The hypothesis is developed that the orbitofrontal cortex has a special role in emotion and decision-making in part because as a cortical area it can implement attractor networks useful in maintaining reward and emotional states online, and in decision- making.
Rapid Rule-Based Reward Reversal and the Lateral Orbitofrontal Cortex
- Psychology, BiologyCerebral cortex communications
- 2020
It is shown in a one-trial rule-based Go-NoGo deterministic visual discrimination reversal task to obtain points, that the human right lateral orbitofrontal cortex and adjoining inferior frontal gyrus is activated on reversal trials, when an expected reward is not obtained, and the non-reward allows the human to switch choices based on a rule.
Commentary on “A non-reward attractor theory of depression”: A proposal to include the habenula connection
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2017
The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons
- Biology, PsychologyNeuroscience & Biobehavioral Reviews
- 2017
The orbitofrontal cortex and emotion in health and disease, including depression
- Psychology, BiologyNeuropsychologia
- 2019
Attractor cortical neurodynamics, schizophrenia, and depression
- PsychologyTranslational Psychiatry
- 2021
In depression, the lateral orbitofrontal cortex non-reward attractor network system is over-connected and has increased sensitivity to non- reward, providing a new approach to understanding depression.
Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression.
- Psychology, BiologyBrain : a journal of neurology
- 2016
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, and it is shown that the functional connectivity of the lateral orbitofrontal cortex Brodmann area 47/12 with these three brain areas was lower in the medicated than the unmedicated patients, consistent with the hypothesis that the increased functional connectivity is related to depression.
The Influence of Neural Reward Processing on Memory in Depression
- Psychology
- 2019
THE INFLUENCE OF NEURAL REWARD PREOCESSING ON MEMORY IN DEPRESSION Nathan M. Hager Old Dominion University, 2019 Director: Dr. Matt. R. Judah Theories and research suggest that depression involves…
References
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Synaptic and spiking dynamics underlying reward reversal in the orbitofrontal cortex.
- Psychology, BiologyCerebral cortex
- 2005
A model at the integrate-and-fire neuronal level of the synaptic and spiking mechanisms which can hold an expectation of a reward rule in working memory, and can reverse the reward rule if expected rewards are not obtained is described.
A biased activation theory of the cognitive and attentional modulation of emotion
- Psychology, BiologyFront. Hum. Neurosci.
- 2013
The stochastic, noisy, dynamics of decision-making systems in the brain may influence whether decisions are made by the selfish-gene-specified reward emotion system, or by the cognitive reasoning system that explicitly calculates reward values that are in the interests of the individual, the phenotype.
Abstract reward and punishment representations in the human orbitofrontal cortex
- Psychology, BiologyNature Neuroscience
- 2001
Findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money.
The orbitofrontal cortex and beyond: From affect to decision-making
- Psychology, BiologyProgress in Neurobiology
- 2008
Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression.
- Psychology, BiologyBrain : a journal of neurology
- 2016
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, and it is shown that the functional connectivity of the lateral orbitofrontal cortex Brodmann area 47/12 with these three brain areas was lower in the medicated than the unmedicated patients, consistent with the hypothesis that the increased functional connectivity is related to depression.
Limbic systems for emotion and for memory, but no single limbic system
- Biology, PsychologyCortex
- 2015
Glutamate, obsessive–compulsive disorder, schizophrenia, and the stability of cortical attractor neuronal networks
- PsychologyPharmacology Biochemistry and Behavior
- 2012
A Dynamical Systems Hypothesis of Schizophrenia
- PsychologyPLoS Comput. Biol.
- 2007
We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states…
Elevated reward-related neural activation as a unique biological marker of bipolar disorder: assessment and treatment implications.
- Psychology, BiologyBehaviour research and therapy
- 2014