A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

@article{Garavito2007ANH,
  title={A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.},
  author={G. Garavito and M. Monje and S. Maurel and A. Valentin and F. Nepveu and E. Deharo},
  journal={Experimental parasitology},
  year={2007},
  volume={116 3},
  pages={
          311-3
        }
}
Intraerythrocytic Plasmodium produces large amounts of toxic heme during the digestion of hemoglobin, a parasite specific pathway. Heme is then partially biocristallized into hemozoin and mostly detoxified by reduced glutathione. We proposed an in vitro micro assay to test the ability of drugs to inhibit heme-glutathione dependent degradation. As glutathione and o-phthalaldehyde form a fluorescent adduct, we followed the extinction of the fluorescent signal when heme was added with or without… Expand
Hemozoin and antimalarial drug discovery.
Electrochemical impedance spectroscopy to study physiological changes affecting the red blood cell after invasion by malaria parasites.
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