A non-proteolytic function of separase links the onset of anaphase to mitotic exit

@article{Sullivan2003ANF,
  title={A non-proteolytic function of separase links the onset of anaphase to mitotic exit},
  author={Matt Sullivan and Frank Uhlmann},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={249-254}
}
Separase is a protease that triggers chromosome segregation at anaphase onset by cleaving cohesin, the chromosomal protein complex responsible for sister chromatid cohesion. After anaphase, cells exit from mitosis; that is, they complete downregulation of cyclin-dependent kinase activity, undergo cytokinesis and enter G1 of the next cell cycle. Here we show that separase activation at the onset of anaphase is sufficient to promote release from the nucleolus and activation of the budding yeast… CONTINUE READING
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the molecular biology of chromosome separation

  • Nasmyth, K. Segregating sister genomes
  • Science 297, 559–565
  • 2002

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