A non-isotopic assay for histone deacetylase activity.

  title={A non-isotopic assay for histone deacetylase activity.},
  author={Kerstin Hoffmann and Gerald Brosch and Peter Loidl and Manfred Jung},
  journal={Nucleic acids research},
  volume={27 9},
Inhibitors of histone deacetylase (HD) bear great potential as new drugs due to their ability to modulate transcription and to induce apoptosis or differentiation in cancer cells. To study the activity of HD and the effect of potential inhibitors in vitro so far only radio-active assays have existed. For the search of new inhibitors and for the use in HD… CONTINUE READING