A non-invasive transport system for GDNF across the blood-brain barrier.

  title={A non-invasive transport system for GDNF across the blood-brain barrier.},
  author={David S Albeck and Barry J. Hoffer and David O. Quissell and Linda A. Sanders and Gary Zerbe and Ann-Charlotte E. Granholm},
  volume={8 9-10},
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophin which supports midbrain dopaminergic neurons and spinal cord motorneurons. GDNF has been proposed as a possible therapeutic agent for Parkinson's disease, spinal cord injury or motorneuron degenerative disorders. Administration of GDNF is complicated by its poor penetration across the blood-brain barrier (BBB). Central nervous system capillaries are uniquely enriched in transferrin receptors and antibodies to these receptors… CONTINUE READING


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