A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin.

@article{Logsdon2006ANQ,
  title={A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin.},
  author={Lauren K. Logsdon and Joan Mecsas},
  journal={Journal of immunological methods},
  year={2006},
  volume={313 1-2},
  pages={
          183-90
        }
}
Intestinal inflammation in mice is most frequently assessed by histology or FACS, processes that necessitate sacrificing mice. We developed a lactoferrin ELISA for murine feces to quantify intestinal inflammation in mice with enteric infections or colitis. Levels of fecal lactoferrin, a protein secreted by activated neutrophils, were consistent with neutrophil infiltration as assessed by histology, indicating that this fecal lactoferrin ELISA is a good alternative to histology. The fecal… CONTINUE READING

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