A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant

@article{Miller1993ANM,
  title={A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant},
  author={Rehae C. Miller and Ric Schaaf and David W. Maughan and Terese R. Tansey},
  journal={Journal of Muscle Research & Cell Motility},
  year={1993},
  volume={14},
  pages={85-98}
}
The tropomyosin I(TmI) gene of Drosophila melanogaster encodes two isoforms of tropomyosin. The Ifm-Tml isoform is expressed only in indirect flight and jump muscles; the Scm-TmI isoform is found in other muscles of the larva and adult. The level of Ifm-TmI is severely reduced in the flightless mutant Ifm(3)3, which also is unable to jump. To explore the functional significance of tropomyosin isoform diversity in Drosophila, we have used P element-mediated transformation to express Scm-TmI in… CONTINUE READING

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