A non-essential function for yeast frataxin in iron-sulfur cluster assembly.

@article{Duby2002ANF,
  title={A non-essential function for yeast frataxin in iron-sulfur cluster assembly.},
  author={Geoffrey Duby and Françoise Foury and Anna Ramazzotti and Johannes M Herrmann and Thomas Lutz},
  journal={Human molecular genetics},
  year={2002},
  volume={11 21},
  pages={2635-43}
}
Friedreich's ataxia is caused by a deficit in frataxin, a small mitochondrial protein of unknown function that has been conserved during evolution. Previous studies have pointed out a role for frataxin in mitochondrial iron-sulfur (Fe-S) metabolism. Here, we have analyzed the incorporation of Fe-S clusters into yeast ferredoxin imported into isolated energized mitochondria from cells grown in the presence of glycerol, an obligatory respiratory carbon source. Similar amounts of apo-ferredoxin… CONTINUE READING