A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

@article{Shim1996ANP,
  title={A non-enzymatic p21 protein inhibitor of stress-activated protein kinases},
  author={Jaekyung Shim and HeeJeong Lee and Jihyun Park and Hanshin Kim and Eui-Ju Choi},
  journal={Nature},
  year={1996},
  volume={381},
  pages={804-807}
}
THE stress-activated protein kinases (SAPKs), which are identical to the c-Jun amino-terminal kinases (JNKs), are activated in response to a variety of cellular stresses, including DNA damage, heat shock or tumour-necrosis factor-α1,2. SAPK, a subfamily of the mitogen-activated protein (MAP) kinases, is a major protein kinase that phosphorylates c-Jun and other transcription factors2–5. SAPK phosphorylation of transcription factors is important in stress-activated signalling cascades1–6. Here… CONTINUE READING

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