A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

@inproceedings{Raiber2012AND,
  title={A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro},
  author={Eun-Ang Raiber and Ramon Kranaster and Enid Lam and Mehran Nikan and Shankar Balasubramanian},
  booktitle={Nucleic acids research},
  year={2012}
}
SP1 is a ubiquitous transcription factor that is involved in the regulation of various house-keeping genes. It is known that it acts by binding to a double-stranded consensus motif. Here, we have discovered that SP1 binds also to a non-canonical DNA structure, a G-quadruplex, with high affinity. In particular, we have studied the SP1 binding site within the promoter region of the c-KIT oncogene and found that this site can fold into an anti-parallel two-tetrad G-quadruplex. SP1 pull-down… CONTINUE READING
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