A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.

@article{Loo2015ANS,
  title={A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.},
  author={Jacky Fong-Chuen Loo and S S Wang and Fang Peng and Jianxin He and L. He and Yanna Guo and Dayong Gu and Ho-chin Kwok and S. Y. Wu and Ho‐Pui Ho and Weidong Xie and Yong-Hong Shao and Siu Kai Kong},
  journal={The Analyst},
  year={2015},
  volume={140 13},
  pages={
          4566-75
        }
}
As in all RNA viruses, influenza viruses change and mutate constantly because their RNA polymerase has no proofreading ability. This poses a serious threat to public health nowadays. In addition, traditional pathogen-based detection methods may not be able to report an infection from an unknown type or a subtype of virus if its nucleotide sequence is not known. Because of these factors, targeting host microRNA signatures may be an alternative to classify infections and distinguish types of… 

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