A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.

@article{Loo2015ANS,
  title={A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.},
  author={J. Loo and S. S. Wang and F. Peng and J. He and L. He and Y. Guo and D. Gu and H. Kwok and S. Y. Wu and H. Ho and W. Xie and Y. Shao and S. Kong},
  journal={The Analyst},
  year={2015},
  volume={140 13},
  pages={
          4566-75
        }
}
As in all RNA viruses, influenza viruses change and mutate constantly because their RNA polymerase has no proofreading ability. This poses a serious threat to public health nowadays. In addition, traditional pathogen-based detection methods may not be able to report an infection from an unknown type or a subtype of virus if its nucleotide sequence is not known. Because of these factors, targeting host microRNA signatures may be an alternative to classify infections and distinguish types of… Expand
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