A non-AUG-defined alternative open reading frame of the intestinal carboxyl esterase mRNA generates an epitope recognized by renal cell carcinoma-reactive tumor-infiltrating lymphocytes in situ.

@article{Ronsin1999ANA,
  title={A non-AUG-defined alternative open reading frame of the intestinal carboxyl esterase mRNA generates an epitope recognized by renal cell carcinoma-reactive tumor-infiltrating lymphocytes in situ.},
  author={Christophe Ronsin and V{\'e}ronique Chung-Scott and Isabelle Poullion and Nicolas Aknouche and Catherine F. M. Gaudin and Fr{\'e}d{\'e}ric Triebel},
  journal={Journal of immunology},
  year={1999},
  volume={163 1},
  pages={483-90}
}
A number of Ags recognized by tumor-reactive T cells have been characterized, including nonmutated gene products and a variety of epitopes shown to arise from either mutated or alternatively processed transcripts. Here, we report that the screening of a cDNA library with an HLA-B7-restricted renal cell carcinoma-reactive T cell clone derived from tumor-infiltrating lymphocytes (TILs) that were clonally amplified in vivo (as assessed by TCRBV complementarity determining region-3 length… CONTINUE READING

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