A nodal-related gene defines a physical and functional domain within the Spemann organizer

@article{Smith1995ANG,
  title={A nodal-related gene defines a physical and functional domain within the Spemann organizer},
  author={William C Smith and Roslyn McKendry and Stephen Ribisi and Richard M Harland},
  journal={Cell},
  year={1995},
  volume={82},
  pages={37-46}
}
A functional screen for gene products that rescue dorsal development in ventralized Xenopus embryos has yielded Xenopus nodal-related 3 (Xnr3), a diverged member of the TGF beta superfamily. Xnr3 is specifically expressed in the Spemann organizer and is only expressed in the epithelial layer of the organizer immediately preceding and extending through gastrulation. Like noggin, Xnr3 can induce muscle in ventral mesoderm explants, consistent with a role in patterning the gastrula. In other ways… CONTINUE READING
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