A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.

@article{Riccio2006ANO,
  title={A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.},
  author={Antonella Riccio and Rebecca Alvania and Bonnie E Lonze and Narendrakumar Ramanan and Taeho Kim and Yunfei Huang and Ted M Dawson and Solomon H Snyder and David D Ginty},
  journal={Molecular cell},
  year={2006},
  volume={21 2},
  pages={283-94}
}
Prevailing views of neurotrophin action hold that the transcription factor CREB is constitutively bound to target genes with transcriptional activation occurring via CREB phosphorylation. However, we report that within several CRE-containing genes, CREB is not constitutively bound. Upon exposure of neurons to brain-derived neurotrophic factor (BDNF), CREB becomes rapidly bound to DNA coincident with phosphorylation at its transcriptional regulatory site, Ser133. This inducible CREB-DNA binding… CONTINUE READING

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