A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.

@article{Furlan2004ANO,
  title={A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis.},
  author={Roberto Furlan and Asli Kurne and Alessandra Bergami and Elena Marta Brambilla and Raffaella Maucci and Laura Elisa Gasparini and Erica Butti and Giancarlo Comi and Ennio Ongini and Gianvito Martino},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={150 1-2},
  pages={10-9}
}
Nitric oxide (NO)-releasing non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to have a safer profile and additional anti-inflammatory and immuno-modulatory properties compared to parent compounds. Preventive treatment of experimental autoimmune encephalomyelitis (EAE)-induced in C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55-with the NO-releasing derivative of flurbiprofen HCT1026 delayed disease onset and significantly decreased… CONTINUE READING