A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity.

@article{Richardson2008ANO,
  title={A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity.},
  author={Anthony R. Richardson and Stephen James Libby and Ferric C Fang},
  journal={Science},
  year={2008},
  volume={319 5870},
  pages={1672-6}
}
Staphylococcus aureus is one of the most successful human pathogens, colonizing 2 billion individuals worldwide and causing invasive infections even in immunocompetent hosts. S. aureus can evade multiple components of host innate immunity, including the antimicrobial radical nitric oxide (NO.) produced by activated phagocytes. We show that S. aureus is capable of metabolically adapting to nitrosative stress by expressing an NO.-inducible L-lactate dehydrogenase (ldh1, SACOL0222) divergently… CONTINUE READING
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