A nine-residue synthetic propeptide enhances secretion efficiency of heterologous proteins in Lactococcus lactis.

@article{Loir1998ANS,
  title={A nine-residue synthetic propeptide enhances secretion efficiency of heterologous proteins in Lactococcus lactis.},
  author={Yves Le Loir and Alexandra Gruss and Stanislas Dusko Ehrlich and Philippe Langella},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 7},
  pages={1895-903}
}
Lactococcus lactis, a gram-positive organism widely used in the food industry, is a potential candidate for the secretion of biologically useful proteins. We examined the secretion efficiency and capacity of L. lactis by using the Staphylococcus aureus nuclease (Nuc) as a heterologous model protein. When expressed in L. lactis from an efficient lactococcal promoter and its native signal peptide, only approximately 60% of total Nuc was present in a secreted form at approximately 5 mg per liter… CONTINUE READING

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