A nine-gene signature predicting clinical outcome in cutaneous melanoma

@article{Brunner2012ANS,
  title={A nine-gene signature predicting clinical outcome in cutaneous melanoma},
  author={G. Brunner and M. Reitz and A. Heinecke and A. Lippold and C. Berking and L. Suter and J. Atzpodien},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2012},
  volume={139},
  pages={249-258}
}
PurposeCurrent histopathological staging of cutaneous melanoma is limited in predicting outcome, and complementary molecular markers are not available for prognostic assessment. The purpose of this study was to identify a quantitative gene expression score in primary melanoma and adjacent stroma that can be used in clinical routine to define, at the time of diagnosis, patient risk and need for therapy.MethodsExpression of 92 candidate genes was quantified by RT-PCR in a training subset of 38… Expand
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