A nexus of progression of chronic kidney disease: tryptophan, profibrotic cytokines, and charcoal.

@article{Schulman2012ANO,
  title={A nexus of progression of chronic kidney disease: tryptophan, profibrotic cytokines, and charcoal.},
  author={Gerald I Schulman},
  journal={Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation},
  year={2012},
  volume={22 1},
  pages={107-13}
}
Fibrosis plays a major role in the pathogenesis of progressive chronic kidney disease (CKD). The inhibition of the renin-angiotensin system, which promotes fibrosis, has become the standard of care in the treatment of patients with CKD. The use of alternative agents capable of blocking the actions of profibrotic cytokines such as transforming growth factor-beta (TGF-β) is also an important strategy that is in its early stages of development. An example of such a drug is AST-120, a charcoal… CONTINUE READING
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