A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines.

@article{Rter2010ANI,
  title={A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines.},
  author={Christian R{\"u}ter and Christoph Buss and Julia Scharnert and Gerhard Heusipp and M Alexander Schmidt},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 13},
  pages={2190-8}
}
Cell-permeable proteins, also called cell-penetrating peptides (CPPs), have the ability to cross cellular membranes, either alone or in association with bioactive cargo. We identified the Yersinia protein YopM as a novel bacterial cell-permeable protein. Here, we describe the ability of isolated recombinant YopM to enter host cells without a requirement for additional factors. This autonomous translocation of YopM was confirmed in several cell types, indicating that it is an intrinsic property… CONTINUE READING