A newly discovered visual cycle necessary for vision during continuous illumination.

@article{Wolf2002AND,
  title={A newly discovered visual cycle necessary for vision during continuous illumination.},
  author={George Wolf},
  journal={Nutrition reviews},
  year={2002},
  volume={60 2},
  pages={62-5}
}
Rhodopsin, the light-sensitive visual pigment of the retina, is activated through photoisomerization of its prosthetic group, 11-cis-retinal, to all-trans-retinal. A protein found in the retinal pigment epithelium named retinal G protein- coupled receptor (RGR) reacts to light in an opposite but parallel way: its prosthetic group, all-trans-retinal, is photoisomerized to 11-cis-retinal. The latter is reduced to 11-cis-retinol by a cis-retinol dehydrogenase that co-purifies with the RGR. The… CONTINUE READING