A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.

  title={A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.},
  author={A. A. Sinha and C. Brautbar and F. Szafer and A. Friedmann and E. Tzfoni and J. Todd and L. Steinman and H. Mcdevitt},
  volume={239 4843},
  • A. A. Sinha, C. Brautbar, +5 authors H. Mcdevitt
  • Published 1988
  • Biology, Medicine
  • Science
  • The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals having an allele associated with susceptibility develop disease. The identification of allelic variants more precisely correlated with disease susceptibility would greatly facilitate clinical screening and diagnosis. Oligonucleotide-primed gene amplification in vitro was used to determine the nucleotide… CONTINUE READING
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