A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization.

@article{Gu2004ANY,
  title={A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization.},
  author={Wei Gu and Yingfeng Deng and Daniel Zenklusen and Robert H Singer},
  journal={Genes & development},
  year={2004},
  volume={18 12},
  pages={1452-65}
}
In yeast Saccharomyces cerevisiae, Ash1p, a protein determinant for mating-type switching, is segregated within the daughter cell nucleus to establish asymmetry of HO expression. The accumulation of Ash1p results from ASH1 mRNA that is sorted as a ribonucleoprotein particle (mRNP or locasome) to the distal tip of the bud where translation occurs. To study the mechanism regulating ASH1 mRNA translation, we isolated the ASH1 locasome and characterized the associated proteins by MALDI-TOF. One of… CONTINUE READING
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