A new view of "dream enactment" in REM sleep behavior disorder.

@article{Blumberg2016ANV,
  title={A new view of "dream enactment" in REM sleep behavior disorder.},
  author={Mark S. Blumberg and Alan M Plumeau},
  journal={Sleep medicine reviews},
  year={2016},
  volume={30},
  pages={
          34-42
        }
}
Patients with REM sleep behavior disorder (RBD) exhibit increased muscle tone and exaggerated myoclonic twitching during REM sleep. In addition, violent movements of the limbs, and complex behaviors that can sometimes appear to involve the enactment of dreams, are associated with RBD. These behaviors are widely thought to result from a dysfunction involving atonia-producing neural circuitry in the brainstem, thereby unmasking cortically generated dreams. Here we scrutinize the assumptions that… Expand
The REM sleep circuit and how its impairment leads to REM sleep behavior disorder
  • Á. Iranzo
  • Medicine, Biology
  • Cell and Tissue Research
  • 2018
TLDR
This review addresses the neuronal substrates of REM sleep generation and modulation and how its impairment may lead to REM sleep behavior disorder. Expand
RBD: A Window into the Dreaming Process
Rapid eye movement sleep behavior disorder (RBD) is often defined as dream-enacting behaviors. However, the dreaming features in RBD are less studied than its motor aspects or than RBD as prodromalExpand
Neural Circuitry Regulating REM Sleep and Its Implication in REM Sleep Behavior Disorder
TLDR
Data indicate that degenerative lesions of the SLD and its descending projections may underlie RBD and that assessing REMs amount and architecture, in addition to motor behavior, may be necessary to track the progression of RBD into alpha-synucleinopathy diseases such as Parkinson’s disease. Expand
The microstructure of REM sleep: Why phasic and tonic?
TLDR
It is shown that phasic and tonic REM periods are remarkably different neural states with respect to environmental alertness, spontaneous and evoked cortical activity, information processing, and seem to contribute differently to the dysfunctions of REM sleep in several neurological and psychiatric disorders. Expand
Local Cortical Activations During REM Sleep and Implications for RBD
Different neuroimaging and intracerebral EEG studies have shown that brain activity during physiologic REM sleep in humans is not temporally and spatially homogeneous. Indeed, some brain regionsExpand
Do animals dream?
TLDR
It is argued that parallels that exist between the phenomenology, physiology, and sleep behaviors during human dreaming provide an avenue to investigate dreaming in non-human animals. Expand
Modulating dream experience: Noninvasive brain stimulation over the sensorimotor cortex reduces dream movement
TLDR
Findings show that a complex temporal reorganization of the motor network co-occurred with the reduction of dream movement, revealing a link between central and peripheral motor processes and movement sensations of the dream self. Expand
REM sleep behaviour disorder
TLDR
This Primer discusses the epidemiology, pathophysiology, diagnosis and management of RBD as well as the relationship and implications of the relationship between idiopathic RBD and neurodegenerative disease. Expand
Do all mammals dream?
TLDR
The application of techniques revealing dream mentation in humans to other mammals, specifically those that exhibit unusual sleep states, may lead to advances in the understanding of the neural underpinnings of dreams and conscious experiences. Expand
Modulating dream experience: Noninvasive brain stimulation over the sensorimotor cortex reduces dream movement
TLDR
Findings reveal that a complex reorganization of the motor network co-occurred with the reduction of dream movement, confirming spatial specificity of the stimulation site and causally interferes with dream movement during REM sleep. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 99 REFERENCES
REM sleep behavior disorder: Motor manifestations and pathophysiology
  • I. Arnulf
  • Psychology, Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2012
TLDR
Patients with REM sleep behavior disorder have higher and faster risk for conversion to Parkinson's disease and dementia with Lewy bodies if abnormalities in dopamine transporter imaging, transcranial sonography, olfaction, and color vision are found at baseline, and they constitute a highly specific target for testing neuroprotective agents. Expand
Beyond Dreams: Do Sleep-Related Movements Contribute to Brain Development?
TLDR
Recent findings that have inspired an elaboration of the ontogenetic hypothesis suggest that in addition to direct brainstem activation of cortex during active sleep, sensory feedback arising from limb twitches produces discrete and substantial activation of somatosensory cortex and, beyond that, of hippocampus. Expand
The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder.
TLDR
An updated integrated model of the mechanisms responsible for PS is proposed and different hypotheses explaining RBD and cataplexy are explored. Expand
Idiopathic REM sleep behavior disorder
TLDR
Small clinical follow-up studies revealed that a proportion of patients with RBD will eventually develop a parkinsonian syndrome or a dementia of Lewy bodies type in the years following the RBD diagnosis, while some patients will never show other neurologic signs within several decades from the R BD onset. Expand
Breakdown in REM sleep circuitry underlies REM sleep behavior disorder
TLDR
Clinical and basic neuroscience evidence indicates that RBD results from breakdown of the network underlying REM sleep atonia, and this finding is important because it opens new avenues for treating RBD and understanding its link to neurodegenerative disorders. Expand
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.
TLDR
The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented. Expand
Role for the red nucleus in motor control during REM sleep
TLDR
It is found that activation of the RN and its glutamatergic neurons increases muscle activity duringREM sleep by increasing the number of phasic twitches, which disrupts the normal pattern of muscle activity seen during REM sleep. Expand
Chronic behavioral disorders of human REM sleep: a new category of parasomnia.
TLDR
These REM sleep neurobehavioral disorders constitute another category of parasomnia, replicate findings from 21 years ago in cats receiving pontine tegmental lesions, and offer additional perspectives on human behavior, neurophysiology, pharmacology, and dream phenomenology. Expand
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder
TLDR
Dreams in patients with REM sleep behavior disorder were characterized by an elevated proportion of aggressive contents, despite normal levels of daytime aggressiveness, which may be related to the hyperactivity of a common neuronal generator. Expand
Restoration of normal motor control in Parkinson's disease during REM sleep.
TLDR
The restored motor control during REM sleep suggests a transient 'levodopa-like' reestablishment of the basal ganglia loop and parkinsonism may disappear by REM sleep-related disjunction between pyramidal and extrapyramidal systems. Expand
...
1
2
3
4
5
...