A new vesicle-loaded hydrogel system suitable for topical applications: preparation and characterization.

  title={A new vesicle-loaded hydrogel system suitable for topical applications: preparation and characterization.},
  author={Maria Carafa and Carlotta Marianecci and Luisa di Marzio and Federica Rinaldi and Chiara Di Meo and Pietro Matricardi and Franco Alhaique and Tommasina Coviello},
  journal={Journal of pharmacy \& pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  volume={14 3},
  • M. Carafa, C. Marianecci, T. Coviello
  • Published 8 September 2011
  • Biology, Chemistry
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
PURPOSE. Aim of this research was to prepare and study drug release from a new formulation consisting of non ionic surfactant vesicular structures, niosomes (NSVs), loaded with model molecules calcein (CALC), nile red (NR), ibuprofen (IBU) or caffeine (CAFF), and embedded in a hydrogel matrix. METHODS. The system locust bean gum/xanthan (1:1), prepared at 60 °C, was used to entrap the vesicles (Tween 20/cholesterol 1:1), loaded with guest molecules and the release profiles were detected at 32… 

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