A new variation in the promoter region, the −604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance

@article{Zavarella2008ANV,
  title={A new variation in the promoter region, the −604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance},
  author={Sara Zavarella and Antonio Petrone and Simona Zampetti and Maria Gueorguiev and Marialuisa Spoletini and Charles A. Mein and Gaetano Leto and M{\'a}rta Korbonits and Raffaella Buzzetti},
  journal={International Journal of Obesity},
  year={2008},
  volume={32},
  pages={663-668}
}
Objective:Previous studies suggested that polymorphisms in the coding region of the preproghrelin were involved in the etiology of obesity and might modulate glucose-induced insulin secretion. We evaluated the association of a new variation, −604C>T, in the promoter region of the ghrelin gene, of Leu72Met (247C>A) and of Gln90Leu (265A>T), all haplotype-tagging single nucleotide polymorphisms (SNPs), with measures of insulin sensitivity in 1420 adult individuals.Research methods:The three SNPs… CONTINUE READING