A new variant of type II von Willebrand disease with aberrant multimeric structure of plasma but not platelet von Willebrand factor (type IIF).

@article{Mannucci1986ANV,
  title={A new variant of type II von Willebrand disease with aberrant multimeric structure of plasma but not platelet von Willebrand factor (type IIF).},
  author={Pier Mannuccio Mannucci and Rossana Lombardi and Augusto B Federici and Judith A. Dent and Theodore S. Zimmerman and Zaverio M. Ruggeri},
  journal={Blood},
  year={1986},
  volume={68 1},
  pages={269-74}
}
A patient with a lifelong bleeding disorder was diagnosed as having Type II von Willebrand disease. The larger multimers of von Willebrand factor were absent from her plasma but present in platelets. A high-resolution electrophoretic technique was used to study the complex structure of individual von Willebrand factor multimers. In normal plasma, each multimer could be resolved into five bands: a more intense central one and four less intense, two moving faster and two slower than the central… CONTINUE READING

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