A new type of synthetic peptide library for identifying ligand-binding activity

  title={A new type of synthetic peptide library for identifying ligand-binding activity},
  author={K. Lam and S. Salmon and E. Hersh and V. Hruby and W. Kazmierski and Richard J. Knapp},
  • K. Lam, S. Salmon, +3 authors Richard J. Knapp
  • Published 1991
  • Chemistry
  • Nature
  • OUR aim was to improve techniques for drug development by facilitating the identification of small molecules that bind with high affinity to acceptor molecules (for example, cell-surface receptors, enzymes, antibodies) and so to mimic or block their interaction with the natural ligand1,2. Previously such small molecules have been characterized individually on a serial basis. The systematic synthesis and screening of peptide libraries of defined structure represents a new approach. For… CONTINUE READING
    1,110 Citations
    Synthetic peptide libraries
    • 4
    Screening of combinatorial peptide libraries: identification of ligands for affinity purification of proteins using a radiological approach.
    • 20


    Peptides on phage: a vast library of peptides for identifying ligands.
    • 834
    • PDF
    Searching for peptide ligands with an epitope library.
    • 1,905
    Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.
    • 1,190
    • PDF
    Designing peptide and protein ligands for biological receptors.
    • 9
    Chemistry and Biology of Peptides
    • 192
    • PDF