• DOI:10.1038/354082A0
Corpus ID: 4364814

A new type of synthetic peptide library for identifying ligand-binding activity

@article{Lam1991ANT,
  title={A new type of synthetic peptide library for identifying ligand-binding activity},
  author={K. Lam and S. Salmon and E. Hersh and V. Hruby and W. Kazmierski and Richard J. Knapp},
  journal={Nature},
  year={1991},
  volume={354},
  pages={82-84}
}

K. Lam, S. Salmon, +3 authors Richard J. Knapp

Published 1991

Chemistry

Nature

OUR aim was to improve techniques for drug development by facilitating the identification of small molecules that bind with high affinity to acceptor molecules (for example, cell-surface receptors, enzymes, antibodies) and so to mimic or block their interaction with the natural ligand1,2. Previously such small molecules have been characterized individually on a serial basis. The systematic synthesis and screening of peptide libraries of defined structure represents a new approach. For… CONTINUE READING

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