A new type of synthetic peptide library for identifying ligand-binding activity

@article{Lam1991ANT,
  title={A new type of synthetic peptide library for identifying ligand-binding activity},
  author={K. Lam and S. Salmon and E. Hersh and V. Hruby and W. Kazmierski and Richard J. Knapp},
  journal={Nature},
  year={1991},
  volume={354},
  pages={82-84}
}
  • K. Lam, S. Salmon, +3 authors Richard J. Knapp
  • Published 1991
  • Chemistry
  • Nature
  • OUR aim was to improve techniques for drug development by facilitating the identification of small molecules that bind with high affinity to acceptor molecules (for example, cell-surface receptors, enzymes, antibodies) and so to mimic or block their interaction with the natural ligand1,2. Previously such small molecules have been characterized individually on a serial basis. The systematic synthesis and screening of peptide libraries of defined structure represents a new approach. For… CONTINUE READING
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