A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication.

@article{Bernt2002ANT,
  title={A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication.},
  author={Kathrin Maria Bernt and M. -Z. Liang and Xun Ye and Shaoheng Ni and Zong-yi Li and Sheng-long Ye and Fang di Hu and Andr{\'e} Lieber},
  journal={Journal of virology},
  year={2002},
  volume={76 21},
  pages={10994-1002}
}
We have developed a new class of adenovirus vectors that selectively replicate in tumor cells. The vector design is based on our recent observation that a variety of human tumor cell lines support DNA replication of adenovirus vectors with deletions of the E1A and E1B genes, whereas primary human cells or mouse liver cells in vivo do not. On the basis of… CONTINUE READING