A new tumor promotion pathway and its inhibitors.

@article{Fujiki1994ANT,
  title={A new tumor promotion pathway and its inhibitors.},
  author={Hirota Fujiki and Masami Suganuma and Atsumasa Komori and Jun Yatsunami and Sachiko Okabe and Tetsuya Ohta and Eisaburo Sueoka},
  journal={Cancer detection and prevention},
  year={1994},
  volume={18 1},
  pages={
          1-7
        }
}
Tumor promotion is a critical point in multistage carcinogenesis in humans. We have identified a common biochemical and molecular tumor promotion mechanism, the okadaic acid pathway, applicable in various organs. Tumor promotion by the okadaic acid class of compounds is mediated through inhibition of protein phosphatases 1 and 2A, resulting in an increase of protein phosphorylation and a subsequent expression of cell proliferation genes. Recently, we demonstrated that okadaic acid induced the… CONTINUE READING

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