A new topological descriptors based model for predicting intestinal epithelial transport of drugs in Caco-2 cell culture.

@article{Ponce2004ANT,
  title={A new topological descriptors based model for predicting intestinal epithelial transport of drugs in Caco-2 cell culture.},
  author={Yovani Marrero Ponce and Miguel Angel Cabrera P{\'e}rez and Vicente Romero Zaldivar and Humberto Gonz{\'a}lez D{\'i}az and Francisco Torrens},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2004},
  volume={7 2},
  pages={186-99}
}
PURPOSE Quantitative Structure-Permeability Relationships (QSPerR) of the intestinal permeability across the (Caco-2) cells monolayer could be obtained by the application of new molecular descriptors. METHOD A novel topologic-molecular approach to computer molecular design ( TOMOCOMD-CARDD ) has been used to estimate the intestinal-epithelial transport of drug in Caco-2 cell culture. RESULTS The Permeability Coefficients in Caco-2 cells (P) for 33 structurally diverse drugs were well… CONTINUE READING