A new thermography-based approach to early detection of cancer utilizing magnetic nanoparticles theory simulation and in vitro validation.

  title={A new thermography-based approach to early detection of cancer utilizing magnetic nanoparticles theory simulation and in vitro validation.},
  author={Ariel Levy and Abraham Dayan and Moshe Ben-David and Israel Gannot},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={6 6},
  • Ariel Levy, A. Dayan, +1 author I. Gannot
  • Published 1 December 2010
  • Materials Science, Medicine
  • Nanomedicine : nanotechnology, biology, and medicine
This work describes the utilization of tumor-specific magnetic nanoparticles together with an alternating magnetic field as a means to thermally mark a tumor so as to detect it using a thermal imaging system. Experiments were conducted using an in vitro tissue model, an inductive heating system, and an infrared camera. The thermal images, recorded by the infrared camera during the experiments, were analyzed using an algorithm that was developed as part of this work. The results show that small… Expand
Biocompatible iron oxide nanoparticles for enhancement of MRI, thermography and thermal ablation
Thermography is a contact free and low cost diagnostic tool for cancer. However it has several disadvantages over other early cancer detection methods like mammography. Relatively low sensitivity forExpand
Magnetic nanoparticles-based acoustical detection and hyperthermic treatment of cancer, in vitro and in vivo studies
Abstract. This paper describes a minimally invasive method for detection and growth inhibition of tumors that utilizes the unique properties of super paramagnetic nanoparticles. To demonstrate theExpand
Infrared thermography based magnetic hyperthermia study in Fe3O4 based magnetic fluids
Abstract Owing to the immense clinical benefits, magnetic hyperthermia is likely to emerge as an alternate cancer therapeutic procedure in the near future. Presently, radio frequency immune fiberExpand
A new method for tumor detection using induced acoustic waves from tagged magnetic nanoparticles.
A sensitive and cost effective magentoacoustic tumor detection method using superparamagnetic nanoparticles is presented, and the method is demonstrated in a phantom by detecting a 5-mm diameter spherical tumor located 3 cm deep. Expand
Enhanced Thermographic Detection of Skin Cancer Through Combining Laser Scanning and Biodegradable Nanoparticles
Through introducing biodegradable magnesium nanoparticles (Mg-NPs) with excellent property in absorbing laser photon, this paper is dedicated to present a laser scanning based thermogaphic strategyExpand
Precise determination of the heat delivery during in vivo magnetic nanoparticle hyperthermia with infrared thermography.
The results indicate that temperature errors as large as [Formula: see text]C can occur if the experiment is not properly designed, and how to precisely monitor temperature with IRT during hyperthermia is shown, which could positively impact heat dosimetry and clinical planning. Expand
Measurement of thermal properties of magnetic nanoparticles using infrared thermal microscopy
Abstract Magnetic nanoparticles (MNPs) are considered promising for biomedical applications such as hyperthermia treatment and disease diagnosis owing to their distinctive thermal properties. ForExpand
Temperature Sensitivity of Magnetic Nanoparticle Hyperthermia Using IR Thermography
Magnetite nanoparticles are extensively studied for their applications in magnetic nanoparticle hyperthermia. However, existing methods involve invasive methods for monitoring the thermal profileExpand
Real-time infrared thermography detection of magnetic nanoparticle hyperthermia in a murine model under a non-uniform field configuration
The results indicate that infrared thermography may be a promising tool for both early cancer detection and forhyperthermia treatment (at least for subcutaneous tumours), since the method permits access to information about the intratumoral temperature during a real-time magnetic hyperthermia as well as to estimate the in vivo nanoparticles SLP. Expand
Tumor Localization Using Magnetic Nanoparticle-Induced Acoustic Signals
A supporting localization algorithm is presented that can provide the clinician with essential tumor location data and could enable a sequential biopsy and prove the feasibility of tumor localization using a time difference of arrival algorithm along with a magnetoacoustic detection scheme. Expand


Magnetic Nanoparticles for Cancer Therapy
Today, technologies based on magnetic nanoparticles (MNPs) are routinely applied to biological systems with diagnostic or therapeutic purposes. The paradigmatic example is the magnetic resonanceExpand
Applying dynamic thermography in the diagnosis of breast cancer.
  • Y. Ohashi, I. Uchida
  • Medicine
  • IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
  • 2000
This study has attempted to increase the interpretation of breast thermography by using thermal recovery and sequential and subtraction thermography, hoping that even small tumors with negative steady-state thermography may appear in dynamic thermography. Expand
Development of Tumor Targeting Magnetic Nanoparticles for Cancer Therapy
Magnetic nanoparticles will heat when activated by an alternating magnetic field (AMF). Systemic delivery of magnetic nanoparticles conjugated to a monoclonal antibody (MAb) offers potential forExpand
Preparation of Tumor-Specific Magnetoliposomes and Their Application for Hyperthermia
Magnetoliposomes (MLs) were conjugated with an antibody fragment to give specificity to a tumor. The antibody fragment was cross-linked to N-(6-maleimidocaproyloxy)-dipalmitoylExpand
Maghemite nanoparticles with very high AC-losses for application in RF-magnetic hyperthermia
Maghemite nanoparticles covalently coated with polyethylene glycol are investigated with respect to different loss processes in magnetic AC-fields. Transmission electron microscopy reveals a narrowExpand
Targeting Hyperthermia for Renal Cell Carcinoma Using Human MN Antigenspecific Magnetoliposomes
Results indicate the G250–FMLs could target renal cell carcinoma cells in vitro and in vivo, and are efficiently applicable to the hyper thermic treatment of carcinoma. Expand
Magnetic nanoparticles for drug delivery
Targeting specific sites in vivo for the delivery of therapeutic compounds presents a major obstacle to the treatment of many diseases. One targeted delivery technique that has gained prominence inExpand
Detecting Breast Cancer from Thermal Infrared Images by Asymmetry Analysis
One of the popular methods for breast cancer detection is to make comparisons between contralateral images. When the images are relatively symmetrical, small asymmetries may indicate a suspiciousExpand
Molecular imaging in the clinical arena.
The potential of molecular imaging is highlighted, recent advances in clinical and preclinical molecular imaging of cancer and atherosclerosis are highlighted, and clinically relevant molecular imaging technologies and imaging agents are provided. Expand
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
The use of bioconjugated nanoparticles for the delivery and targeting of anticancer drugs and imaging contrast agents is discussed. Expand