A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.

@article{Wodarz2000ANT,
  title={A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment.},
  author={Dominik Wodarz and Karen M. Page and Ramy A. Arnaout and Allan Randrup Thomsen and Jeffrey D Lifson and Martin A. Nowak},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2000},
  volume={355 1395},
  pages={329-43}
}
We use simple mathematical models to examine the dynamics of primary and secondary cytotoxic T-lymphocyte (CTL) responses to viral infections. In particular, we are interested in conditions required to resolve the infection and to protect the host upon secondary challenge. While protection against reinfection is only effective in a restricted set of circumstances, we find that resolution of the primary infection requires persistence of CTL precursors (GTLp), as well as a fast rate of activation… CONTINUE READING

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