A new theory of carcinogenesis*

@article{Holliday1979ANT,
  title={A new theory of carcinogenesis*},
  author={R. Holliday},
  journal={Environmental Health Perspectives},
  year={1979},
  volume={107},
  pages={A196 - A201}
}
Although many carcinogens are mutagens, there is no direct evidence that the cancer-cell phenotype is the result of gene mutation. Transplantation experiments have strongly indicated that malignant cells can arise or revert to the normal phenotype in the absence of mutation. It is suggested that damage to DNA followed by repair triggers the epigenetic changes in gene expression which are responsible for malignancy. We previously proposed that methylation of specific DNA sequences adjacent to… CONTINUE READING

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