A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

@inproceedings{Fuentes2016ANS,
  title={A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop},
  author={Paulina Fuentes and Fei Zhou and Alexander Erban and Daniel Karcher and Joachim Kopka and Ralph Bock},
  booktitle={eLife},
  year={2016}
}
Artemisinin-based therapies are the only effective treatment for malaria, the most devastating disease in human history. To meet the growing demand for artemisinin and make it accessible to the poorest, an inexpensive and rapidly scalable production platform is urgently needed. Here we have developed a new synthetic biology approach, combinatorial supertransformation of transplastomic recipient lines (COSTREL), and applied it to introduce the complete pathway for artemisinic acid, the precursor… CONTINUE READING

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