A new sustained-release preparation of human growth hormone and its pharmacokinetic, pharmacodynamic and safety profile.


OBJECTIVE Adult GH replacement is currently given by daily subcutaneous (sc) injections. Recently, sustained-release (SR) preparations of GH have been developed, the preparations being characterized by a dominant early release, resulting in supraphysiological early GH peaks, and a rapid decline thereafter. We present data on a new SR GH preparation… (More)