A new surface plasmon resonance sensor for high-throughput screening applications.

@article{Piliarik2005ANS,
  title={A new surface plasmon resonance sensor for high-throughput screening applications.},
  author={Marek Piliarik and Hana Vaisocherov{\'a} and Jiř{\'i} Homola},
  journal={Biosensors & bioelectronics},
  year={2005},
  volume={20 10},
  pages={2104-10}
}
We report a new high-throughput surface plasmon resonance (SPR) sensor based on combination of SPR imaging with polarization contrast and a spatially patterned multilayer SPR structure. We demonstrate that this approach offers numerous advantageous features including high-contrast SPR images suitable for automated computer analysis, minimum crosstalk between neighboring sensing channels and inherent compensation for light level fluctuations. Applications of a laboratory prototype of the high… CONTINUE READING
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